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KMID : 0363219770150010031
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Korean Journal of Dermatology
1977 Volume.15 No. 1 p.31 ~ p.38
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A Study on Histopathology and NBT dye Reduction Test in Patients with Pustular Eruptions of Palms and Soles
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김연희/Kim, Yon Hee
김명실/김원석/박효숙/Kim, Myung Sil/Kim, Won Suk/Park, Hyo Sook
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Abstract
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For many years there has been a great deal of disagreement about the classification and histology of recalcitrant pustular eruptions of the palms and soles and the relation of this condition to psoriasis.
It is the purpose of this investigation to describe histological changes in fresh pustules from patients with pustular eruptions of the palms and soles and compare these changes between patients with clinically preceding or co-existing psoriasis (4cases) and without clinically preceding or co-existing psoriasis (7ca.ses). Nine biopsies of pustules were examined and the results were compared between two groups. Histopathological findings were otherwise uniform and typical intradermal well-delineated pustules. No significant differences were found between the two groups. In view of the uniform histology, the unknown etiology, and uncertain clinical classification, the authors prefer the clearly descreptive term pustulosis palinaris et plantaris(PPP).
Recently the phagocytic ability of neutrophilic leukocytes was reported to be impaired in patients suffering from pustular eruptions of the palms and soles. In our study this ability was performed with the aid of the NBT dye reduction test before and after administration of Descresept (aristolochic acid). The aim acitivity of PPP. The results were as follows:
1. In 6, of 11 patients, clinical improvement was accompanied with increasing NBT scores.
2. In 2 of 11 patients, clinical aggravation. was noted in spite of Descresept administration. In these 2 cases, increase in dosage of Descresept made clinical improvement again with increasing NBT scores.
3. In 3 of the 11 patients, there was noted clinical improvement, but NBT scores were slightly decreased.
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